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MASTL antibody (C-Term)

MASTL Reactivity: Human, Mouse WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6259099
  • Target See all MASTL Antibodies
    MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))
    Binding Specificity
    • 8
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 45
    • 18
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 45
    • 14
    Rabbit
    Clonality
    • 44
    • 15
    Polyclonal
    Conjugate
    • 25
    • 7
    • 6
    • 5
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MASTL antibody is un-conjugated
    Application
    • 45
    • 37
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    MASTL Antibody detects endogenous levels of total MASTL.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human MASTL, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product MASTL Primary Antibody
  • Application Notes
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    MASTL (Microtubule Associated serine/threonine Kinase-Like (MASTL))
    Alternative Name
    MASTL (MASTL Products)
    Synonyms
    GW antibody, GWL antibody, MAST-L antibody, im:7149025 antibody, wu:fa02a12 antibody, zgc:100990 antibody, MASTL antibody, GREATWALL antibody, RP11-85G18.2 antibody, THC2 antibody, hGWL antibody, 2700091H24Rik antibody, C88295 antibody, greatwall antibody, thc2 antibody, microtubule associated serine/threonine kinase-like antibody, microtubule associated serine/threonine kinase like antibody, serine/threonine-protein kinase greatwall antibody, microtubule associated serine/threonine kinase like L homeolog antibody, mastl antibody, MASTL antibody, LOC100541707 antibody, Mastl antibody, mastl.L antibody
    Background

    Description: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro, however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.

    Gene: MASTL

    Molecular Weight
    97 kDa
    Gene ID
    84930
    UniProt
    Q96GX5
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