FOLR1 antibody (Internal Region)

Catalog No. ABIN6258796

Product Details anti-FOLR1 Antibody

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Binding Specificity: Internal Region

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOLR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: FOLR1 Antibody detects endogenous levels of total FOLR1.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human FOLR1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for FOLR1

Target: FOLR1 (Folate Receptor 1 (Adult) (FOLR1))

Alternative Name: FOLR1 (FOLR1 Products)

Synonyms: FBP antibody, FOLR antibody, fbp antibody, folr antibody, folr1 antibody, FBP1 antibody, Folbp-1 antibody, Folbp1 antibody, Fbp1 antibody, FOLR1 antibody, Folr1 antibody, folate receptor 1 antibody, folate receptor 1 (adult) antibody, folate receptor 1 (adult) L homeolog antibody, zgc:165502 antibody, Folate receptor alpha antibody, folate receptor alpha antibody, FOLR1 antibody, folr1 antibody, folr1.L antibody, zgc:165502 antibody, Folr1 antibody, LOC100066084 antibody, LOC100725439 antibody

Background:

Description: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral  pH . Exposure to slightly acidic  pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.

Gene: FOLR1

Molecular Weight: 34 kDa

Gene ID: 2348

UniProt: P15328

Pathways: Dicarboxylic Acid Transport