CHRNA10 antibody (C-Term)

Catalog No. ABIN6258708

Product Details anti-CHRNA10 Antibody

Target: CHRNA10 (Cholinergic Receptor, Nicotinic, alpha 10 (CHRNA10))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRNA10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: CHRNA10 Antibody detects endogenous levels of total CHRNA10.

Predicted Reactivity: Pig,Bovine,Horse,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CHRNA10, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CHRNA10

Target: CHRNA10 (Cholinergic Receptor, Nicotinic, alpha 10 (CHRNA10))

Alternative Name: CHRNA10 (CHRNA10 Products)

Synonyms: si:dkey-24p1.3 antibody, ALPHA 10 nAChR antibody, cholinergic receptor, nicotinic, alpha polypeptide 10 antibody, cholinergic receptor nicotinic alpha 10 subunit antibody, cholinergic receptor, nicotinic, alpha 10a antibody, neuronal acetylcholine receptor subunit alpha-10 antibody, cholinergic receptor, nicotinic, alpha 10 (neuronal) antibody, Chrna10 antibody, CHRNA10 antibody, chrna10a antibody, LOC100344381 antibody

Background:

Description: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

Gene: CHRNA10

Molecular Weight: 50 kDa

Gene ID: 57053

UniProt: Q9GZZ6

Pathways: Sensory Perception of Sound, Synaptic Membrane