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TSEN54 antibody (Internal Region)

TSEN54 Reactivity: Human, Mouse WB, IHC, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6258653
  • Target See all TSEN54 Antibodies
    TSEN54 (tRNA Splicing Endonuclease 54 (TSEN54))
    Binding Specificity
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 13
    • 8
    • 1
    Human, Mouse
    Host
    • 12
    • 1
    Rabbit
    Clonality
    • 13
    Polyclonal
    Conjugate
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TSEN54 antibody is un-conjugated
    Application
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    TSEN54 Antibody detects endogenous levels of total TSEN54.
    Predicted Reactivity
    Bovine
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human TSEN54, corresponding to a region within the internal amino acids.
    Isotype
    IgG
  • Application Notes
    WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    TSEN54 (tRNA Splicing Endonuclease 54 (TSEN54))
    Alternative Name
    TSEN54 (TSEN54 Products)
    Synonyms
    zgc:109927 antibody, 0610034P02Rik antibody, PCH2A antibody, PCH4 antibody, SEN54L antibody, sen54 antibody, tRNA splicing endonuclease subunit 54 antibody, TSEN54 tRNA splicing endonuclease subunit antibody, tRNA splicing endonuclease 54 homolog (S. cerevisiae) antibody, TSEN54 antibody, tsen54 antibody, Tsen54 antibody
    Background

    Description: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.

    Gene: TSEN54

    Molecular Weight
    59 kDa
    Gene ID
    283989
    UniProt
    Q7Z6J9
    Pathways
    Synaptic Membrane
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