POU4F1 antibody (Internal Region)
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- Target See all POU4F1 Antibodies
- POU4F1 (POU Domain, Class 4, Transcription Factor 1 (POU4F1))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This POU4F1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- POU4F1 Antibody detects endogenous levels of total POU4F1.
- Predicted Reactivity
- Pig,Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human POU4F1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product POU4F1 Primary Antibody
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- Application Notes
- WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- POU4F1 (POU Domain, Class 4, Transcription Factor 1 (POU4F1))
- Alternative Name
- POU4F1 (POU4F1 Products)
- Synonyms
- BRN3A antibody, Oct-T1 antibody, RDC-1 antibody, brn-3A antibody, POU4F1 antibody, Brn-3a antibody, Brn-3 antibody, Brn-3.0 antibody, Brn3 antibody, Brn3.0 antibody, Brn3a antibody, E130119J07Rik antibody, brn3.0 antibody, brn3a antibody, brn3a-A antibody, oct-t1 antibody, rdc-1 antibody, POU class 4 homeobox 1 antibody, POU domain, class 4, transcription factor 1 antibody, POU class 4 homeobox 1 L homeolog antibody, POU4F1 antibody, Pou4f1 antibody, pou4f1 antibody, Tsp_01181 antibody, pou4f1.L antibody
- Background
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Description: Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site.
Gene: POU4F1
- Molecular Weight
- 42 kDa
- Gene ID
- 5457
- UniProt
- Q01851
- Pathways
- Feeding Behaviour
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