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ULK3 antibody (Internal Region)

ULK3 Reactivity: Human, Mouse WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6258344
  • Target See all ULK3 Antibodies
    ULK3 (Unc-51-Like Kinase 3 (ULK3))
    Binding Specificity
    • 13
    • 11
    • 8
    • 8
    • 7
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 54
    • 45
    • 16
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Mouse
    Host
    • 61
    • 7
    • 2
    Rabbit
    Clonality
    • 64
    • 6
    Polyclonal
    Conjugate
    • 31
    • 6
    • 6
    • 6
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ULK3 antibody is un-conjugated
    Application
    • 61
    • 39
    • 10
    • 9
    • 8
    • 6
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    ULK3 Antibody detects endogenous levels of total ULK3.
    Predicted Reactivity
    Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human ULK3, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product ULK3 Primary Antibody
  • Application Notes
    WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    ULK3 (Unc-51-Like Kinase 3 (ULK3))
    Alternative Name
    ULK3 (ULK3 Products)
    Synonyms
    zgc:162196 antibody, 1200015E14Rik antibody, unc-51 like kinase 3 antibody, unc-51 like kinase 3 L homeolog antibody, unc-51-like kinase 3 antibody, ULK3 antibody, ulk3 antibody, Ulk3 antibody, ulk3.L antibody
    Background

    Description: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.

    Gene: ULK3

    Molecular Weight
    24 kDa
    Gene ID
    25989
    UniProt
    Q6PHR2
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