TACC3 antibody (C-Term)

Catalog No. ABIN6258335

Product Details anti-TACC3 Antibody

Target: TACC3 (Transforming, Acidic Coiled-Coil Containing Protein 3 (TACC3))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TACC3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)

Specificity: TACC3 Antibody detects endogenous levels of total TACC3.

Predicted Reactivity: Bovine,Horse,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TACC3, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for TACC3

Target: TACC3 (Transforming, Acidic Coiled-Coil Containing Protein 3 (TACC3))

Alternative Name: TACC3 (TACC3 Products)

Synonyms: Aint antibody, C86661 antibody, Eric1 antibody, ERIC-1 antibody, ERIC1 antibody, maskin antibody, masking antibody, xmaskin antibody, transforming, acidic coiled-coil containing protein 3 antibody, transforming acidic coiled-coil containing protein 3 antibody, transforming acidic coiled-coil containing protein 3 S homeolog antibody, Tacc3 antibody, TACC3 antibody, tacc3.S antibody

Background:

Description: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).

Gene: TACC3

Molecular Weight: 80 kDa

Gene ID: 10460

UniProt: Q9Y6A5

Pathways: Maintenance of Protein Location