PHLDA3 antibody (C-Term)
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- Target See all PHLDA3 Antibodies
- PHLDA3 (Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PHLDA3 antibody is un-conjugated
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Application
- ELISA, Western Blotting (WB)
- Specificity
- PHLDA3 Antibody detects endogenous levels of total PHLDA3.
- Predicted Reactivity
- Pig,Rabbit
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human PHLDA3, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product PHLDA3 Primary Antibody
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- Application Notes
- WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- PHLDA3 (Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3))
- Alternative Name
- PHLDA3 (PHLDA3 Products)
- Synonyms
- TIH1 antibody, Tih1 antibody, si:dz182n13.5 antibody, zgc:92333 antibody, pleckstrin homology like domain family A member 3 antibody, pleckstrin homology like domain, family A, member 3 antibody, pleckstrin homology-like domain, family A, member 3 antibody, PHLDA3 antibody, Phlda3 antibody, phlda3 antibody
- Background
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Description: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.
Gene: PHLDA3
- Molecular Weight
- 14 kDa
- Gene ID
- 23612
- UniProt
- Q9Y5J5
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