PHLDA3 antibody (C-Term)

Catalog No. ABIN6258301

This anti-PHLDA3 antibody is a Rabbit Polyclonal antibody detecting PHLDA3 in ELISA and WB. Suitable for Human, Mouse and Rat.

Quick Overview for PHLDA3 antibody (C-Term) (ABIN6258301)

Target: PHLDA3 (Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHLDA3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-PHLDA3 Antibody

Binding Specificity: C-Term

Specificity: PHLDA3 Antibody detects endogenous levels of total PHLDA3.

Predicted Reactivity: Pig,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PHLDA3, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for PHLDA3

Target: PHLDA3 (Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3))

Alternative Name: PHLDA3

Background:

Description: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.

Gene: PHLDA3

Molecular Weight: 14 kDa

Gene ID: 23612

UniProt: Q9Y5J5