GPR56 antibody
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- Target See all GPR56 Antibodies
- GPR56 (G Protein-Coupled Receptor 56 (GPR56))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GPR56 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificity
- GPR56 antibody detects endogenous levels of total GPR56
- Cross-Reactivity
- Human
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide
- Isotype
- IgG
- Top Product
- Discover our top product GPR56 Primary Antibody
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- Application Notes
- WB 1:500-1:2000 IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- Target
- GPR56 (G Protein-Coupled Receptor 56 (GPR56))
- Alternative Name
- GPR56 (GPR56 Products)
- Synonyms
- fc49b10 antibody, wu:fc49b10 antibody, BFPP antibody, TM7LN4 antibody, TM7XN1 antibody, Cyt28 antibody, GPR56 antibody, adhesion G protein-coupled receptor G1 antibody, G protein-coupled receptor 56 antibody, ADGRG1 antibody, adgrg1 antibody, Adgrg1 antibody, GPR56 antibody
- Background
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Description: Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (PubMed:22238662). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (PubMed:16757564, PubMed:21724588). Plays an essential role in testis development (By similarity).
Gene: ADGRG1
- Molecular Weight
- 78 kDa
- Gene ID
- 9289
- UniProt
- Q9Y653
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