DYRK3 antibody

Catalog No. ABIN6258128

Product Details anti-DYRK3 Antibody

Target: DYRK3 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYRK3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: RED Antibody detects endogenous levels of total RED

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide

Isotype: IgG

Application Details

Application Notes: WB 1:500~1:1000, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for DYRK3

Target: DYRK3 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3))

Alternative Name: RED (DYRK3 Products)

Synonyms: DYRK5 antibody, RED antibody, REDK antibody, hYAK3-2 antibody, BC006704 antibody, DYRK3 antibody, MGC89944 antibody, dual specificity tyrosine phosphorylation regulated kinase 3 antibody, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 antibody, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 antibody, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 L homeolog antibody, DYRK3 antibody, Dyrk3 antibody, dyrk3 antibody, dyrk3.L antibody

Background:

Description: Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353).

Gene: IK

Molecular Weight: 66 kDa

Gene ID: 3550

UniProt: Q13123

Pathways: Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha