DLX5 antibody (Internal Region)

Catalog No. ABIN6258115

Product Details anti-DLX5 Antibody

Target: DLX5 (Distal-Less Homeobox 5 (DLX5))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLX5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: DLX5 Antibody detects endogenous levels of total DLX5.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human DLX5, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

References for anti-DLX5 antibody (ABIN6258115)

Miwa, Ito, Ohta: "Tsukushi is essential for the formation of the posterior semicircular canal that detects gait performance." in: Journal of cell communication and signaling, (2021) (PubMed).

Target Details for DLX5

Target: DLX5 (Distal-Less Homeobox 5 (DLX5))

Alternative Name: DLX5 (DLX5 Products)

Synonyms: SHFM1D antibody, AI385752 antibody, RDLX antibody, X-dll3 antibody, dll3 antibody, MGC69418 antibody, DLX5 antibody, dlx5 antibody, dlx4 antibody, zgc:101787 antibody, distal-less homeobox 5 antibody, distal-less homeobox 5 L homeolog antibody, distal-less homeobox 2b antibody, distal-less homeobox 5a antibody, DLX5 antibody, Dlx5 antibody, dlx5.L antibody, dlx5 antibody, dlx2b antibody, dlx5a antibody

Background:

Description: Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.

Gene: DLX5

Molecular Weight: 32 kDa

Gene ID: 1749

UniProt: P56178