PRKG2 antibody (N-Term)
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- Target See all PRKG2 Antibodies
- PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PRKG2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- CGK2 Antibody detects endogenous levels of total CGK2.
- Predicted Reactivity
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human CGK2, corresponding to a region within N-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product PRKG2 Primary Antibody
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- Application Notes
- WB 1:500-1:1000, ELISA(peptide) 1:20000-1:40000, IF/ICC 1:100-1:500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))
- Alternative Name
- PRKG2 (PRKG2 Products)
- Synonyms
- MGC82580 antibody, PRKG2 antibody, si:dkey-18e17.2 antibody, PRKGR2 antibody, cGKII antibody, GDPKII antibody, AW212535 antibody, CGKII antibody, Prkgr2 antibody, cGK-II antibody, protein kinase, cGMP-dependent, type II antibody, protein kinase, cGMP-dependent, type II L homeolog antibody, cGMP-dependent protein kinase 2 antibody, PRKG2 antibody, prkg2.L antibody, prkg2 antibody, LOC100541294 antibody, Prkg2 antibody
- Background
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Description: Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).
Gene: PRKG2
- Molecular Weight
- 87 kDa
- Gene ID
- 5593
- UniProt
- Q13237
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