TRIO antibody (Internal Region)

Catalog No. ABIN6257891

Product Details anti-TRIO Antibody

Target: TRIO (Triple Functional Domain Protein (TRIO))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIO antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC)

Specificity: TRIO Antibody detects endogenous levels of total TRIO.

Predicted Reactivity: Pig,Zebrafish,Horse,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TRIO, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for TRIO

Target: TRIO (Triple Functional Domain Protein (TRIO))

Alternative Name: TRIO (TRIO Products)

Synonyms: ARHGEF23 antibody, tgat antibody, 6720464I07Rik antibody, AA408740 antibody, Solo antibody, si:dz230d15.1 antibody, trio Rho guanine nucleotide exchange factor antibody, triple functional domain (PTPRF interacting) antibody, trio Rho guanine nucleotide exchange factor b antibody, TRIO antibody, Trio antibody, triob antibody

Background:

Description: Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity).

Gene: TRIO

Molecular Weight: 31 kDa

Gene ID: 7204

UniProt: O75962