TRIP13 antibody (C-Term)

Catalog No. ABIN6257873

Product Details anti-TRIP13 Antibody

Target: TRIP13 (Thyroid Hormone Receptor Interactor 13 (TRIP13))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIP13 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: TRIP13 Antibody detects endogenous levels of total TRIP13.

Predicted Reactivity: Bovine,Horse,Sheep,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TRIP13, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for TRIP13

Target: TRIP13 (Thyroid Hormone Receptor Interactor 13 (TRIP13))

Alternative Name: TRIP13 (TRIP13 Products)

Synonyms: im:6901078 antibody, zgc:65952 antibody, 16e1bp antibody, pch2 antibody, trip-13 antibody, TRIP13 antibody, 16E1BP antibody, PCH2 antibody, TRIP-13 antibody, 2410002G23Rik antibody, D13Ertd328e antibody, thyroid hormone receptor interactor 13 antibody, pachytene checkpoint protein 2 homolog antibody, pachytene checkpoint protein 2 homolog pseudogene antibody, thyroid hormone receptor interactor 13 L homeolog antibody, trip13 antibody, TRIP13 antibody, LOC742208 antibody, CMU_027690 antibody, MCYG_05496 antibody, LOC100348391 antibody, trip13.L antibody, Trip13 antibody

Background:

Description: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed:28553959).

Gene: TRIP13

Molecular Weight: 48 kDa

Gene ID: 9319

UniProt: Q15645