Apoptosis Inhibitor 5 antibody (C-Term)

Catalog No. ABIN6257683

Product Details anti-Apoptosis Inhibitor 5 Antibody

Target: Apoptosis Inhibitor 5 (API5)

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Apoptosis Inhibitor 5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: API-5 Antibody detects endogenous levels of total API-5.

Predicted Reactivity: Pig,Horse,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human API-5, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for Apoptosis Inhibitor 5

Target: Apoptosis Inhibitor 5 (API5)

Alternative Name: API5 (API5 Products)

Synonyms: AAC-11 antibody, AAC11 antibody, AI196452 antibody, api5l1 antibody, sr:nyz021 antibody, zgc:66211 antibody, wu:fb26c03 antibody, API-5B antibody, aac-11 antibody, aac11 antibody, api5 antibody, API-5A antibody, api5-A antibody, MGC83290 antibody, API5 antibody, apoptosis inhibitor 5 antibody, apoptosis inhibitor 5 S homeolog antibody, apoptosis inhibitor 5 L homeolog antibody, API5 antibody, Api5 antibody, api5 antibody, api5.S antibody, api5.L antibody

Background:

Description: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.

Gene: API5

Molecular Weight: 58 kDa

Gene ID: 8539

UniProt: Q9BZZ5

Pathways: Growth Factor Binding