ZFYVE19 antibody (Internal Region)

Catalog No. ABIN6257582

Product Details anti-ZFYVE19 Antibody

Target: ZFYVE19 (Zinc Finger, FYVE Domain Containing 19 (ZFYVE19))

Binding Specificity: Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZFYVE19 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: ZFYVE19 Antibody detects endogenous levels of total ZFYVE19.

Predicted Reactivity: Horse,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ZFYVE19, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for ZFYVE19

Target: ZFYVE19 (Zinc Finger, FYVE Domain Containing 19 (ZFYVE19))

Alternative Name: ZFYVE19 (ZFYVE19 Products)

Synonyms: ZFYVE19 antibody, mpfyve antibody, DKFZp469E1112 antibody, MPFYVE antibody, 1500041L05Rik antibody, zinc finger FYVE-type containing 19 antibody, zinc finger FYVE domain containing 19 antibody, zinc finger, FYVE domain containing 19 antibody, ZFYVE19 antibody, Zfyve19 antibody, zfyve19 antibody

Background:

Description: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.

Gene: ZFYVE19

Molecular Weight: 50 kDa

Gene ID: 84936

UniProt: Q96K21