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VRK2 antibody (Internal Region)

VRK2 Reactivity: Human, Mouse WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6257548
  • Target See all VRK2 Antibodies
    VRK2 (Vaccinia Related Kinase 2 (VRK2))
    Binding Specificity
    • 15
    • 8
    • 7
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 32
    • 19
    • 1
    Human, Mouse
    Host
    • 45
    • 2
    • 1
    Rabbit
    Clonality
    • 47
    • 1
    Polyclonal
    Conjugate
    • 15
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This VRK2 antibody is un-conjugated
    Application
    • 38
    • 24
    • 13
    • 13
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    VRK2 Antibody detects endogenous levels of total VRK2.
    Predicted Reactivity
    Horse,Sheep
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human VRK2, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product VRK2 Primary Antibody
  • Application Notes
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    VRK2 (Vaccinia Related Kinase 2 (VRK2))
    Alternative Name
    VRK2 (VRK2 Products)
    Synonyms
    2810003O05Rik antibody, AI447698 antibody, vaccinia related kinase 2 antibody, VRK2 antibody, Vrk2 antibody
    Background

    Description: Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.

    Gene: VRK2

    Molecular Weight
    55 kDa
    Gene ID
    7444
    UniProt
    Q86Y07
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