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RNF138 antibody (Internal Region)

RNF138 Reactivity: Human, Mouse, Rat WB, ELISA, ICC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6257503
  • Target See all RNF138 Antibodies
    RNF138 (Ring Finger Protein 138 (RNF138))
    Binding Specificity
    • 15
    • 9
    • 7
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 54
    • 23
    • 23
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 51
    • 3
    Rabbit
    Clonality
    • 53
    • 1
    Polyclonal
    Conjugate
    • 19
    • 6
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RNF138 antibody is un-conjugated
    Application
    • 41
    • 22
    • 13
    • 4
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    RNF138 Antibody detects endogenous levels of total RNF138.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human RNF138, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product RNF138 Primary Antibody
  • Application Notes
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    RNF138 (Ring Finger Protein 138 (RNF138))
    Alternative Name
    RNF138 (RNF138 Products)
    Synonyms
    2410015A17Rik antibody, 2810480D20Rik antibody, STRIN antibody, Trif antibody, Trif-d antibody, HSD-4 antibody, NARF antibody, hNARF antibody, Rsd4 antibody, narf antibody, ring finger protein 138 antibody, ring finger protein 138 S homeolog antibody, RNF138 antibody, Rnf138 antibody, rnf138.S antibody
    Background

    Description: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285).

    Gene: RNF138

    Molecular Weight
    28 kDa
    Gene ID
    51444
    UniProt
    Q8WVD3
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