PNN antibody (Internal Region)
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- Target See all PNN Antibodies
- PNN (Pinin, Desmosome Associated Protein (PNN))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PNN antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- PNN Antibody detects endogenous levels of total PNN.
- Predicted Reactivity
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human PNN, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product PNN Primary Antibody
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- Application Notes
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- PNN (Pinin, Desmosome Associated Protein (PNN))
- Alternative Name
- PNN (PNN Products)
- Synonyms
- DRS antibody, DRSP antibody, SDK3 antibody, memA antibody, wu:fb24d03 antibody, pnn antibody, MGC88923 antibody, PNN antibody, AU045199 antibody, D12Ertd512e antibody, CG8383 antibody, Dmel\\CG8383 antibody, dPnn antibody, pinin, desmosome associated protein antibody, pinin antibody, Pinin antibody, PNN antibody, Pnn antibody, pnn antibody, LOC100380709 antibody
- Background
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Description: Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene, the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
Gene: PNN
- Molecular Weight
- 85 kDa
- Gene ID
- 5411
- UniProt
- Q9H307
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