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MAPKSP1 antibody (Internal Region)

MAPKSP1 Reactivity: Human, Mouse, Rat WB, ELISA, ICC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6257364
  • Target See all MAPKSP1 Antibodies
    MAPKSP1 (Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 (MAPKSP1))
    Binding Specificity
    • 15
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 26
    • 18
    • 11
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 30
    • 3
    Rabbit
    Clonality
    • 30
    • 3
    Polyclonal
    Conjugate
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAPKSP1 antibody is un-conjugated
    Application
    • 13
    • 13
    • 11
    • 10
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    LAMTOR3 Antibody detects endogenous levels of total LAMTOR3.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human LAMTOR3, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product MAPKSP1 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Expiry Date
    12 months
  • Target
    MAPKSP1 (Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 (MAPKSP1))
    Alternative Name
    LAMTOR3 (MAPKSP1 Products)
    Synonyms
    MAPKSP1 antibody, MAP2K1IP1 antibody, MAPBP antibody, MP1 antibody, PRO0633 antibody, Ragulator3 antibody, AW556229 antibody, Map2k1ip1 antibody, Mapbp antibody, Mapksp1 antibody, Mp1 antibody, mapksp1 antibody, zgc:110207 antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 antibody, LAMTOR3 antibody, Lamtor3 antibody, lamtor3 antibody
    Background

    Description: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.

    Gene: LAMTOR3

    Gene ID
    8649
    UniProt
    Q9UHA4
    Pathways
    PI3K-Akt Signaling
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