MAPKSP1 antibody (Internal Region)

Catalog No. ABIN6257364

Product Details anti-MAPKSP1 Antibody

Target: MAPKSP1 (Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 (MAPKSP1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPKSP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: LAMTOR3 Antibody detects endogenous levels of total LAMTOR3.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human LAMTOR3, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for MAPKSP1

Target: MAPKSP1 (Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 (MAPKSP1))

Alternative Name: LAMTOR3 (MAPKSP1 Products)

Synonyms: MAPKSP1 antibody, MAP2K1IP1 antibody, MAPBP antibody, MP1 antibody, PRO0633 antibody, Ragulator3 antibody, AW556229 antibody, Map2k1ip1 antibody, Mapbp antibody, Mapksp1 antibody, Mp1 antibody, mapksp1 antibody, zgc:110207 antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 antibody, LAMTOR3 antibody, Lamtor3 antibody, lamtor3 antibody

Background:

Description: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.

Gene: LAMTOR3

Gene ID: 8649

UniProt: Q9UHA4

Pathways: PI3K-Akt Signaling