MYST2 antibody (Internal Region)

Catalog No. ABIN6257254

Product Details anti-MYST2 Antibody

Target: MYST2 (MYST Histone Acetyltransferase 2 (MYST2))

Binding Specificity: Internal Region

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYST2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: MYST2 Antibody detects endogenous levels of total MYST2.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human MYST2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

References for anti-MYST2 antibody (ABIN6257254)

Yang, Guan, Shaikh, Liang, Sun, Wang, Li, Qiu, Li: "Histone Acetyltransferase Mof Affects the Progression of DSS-Induced Colitis." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 47, Issue 5, pp. 2159-2169, (2018) (PubMed).

Target Details for MYST2

Target: MYST2 (MYST Histone Acetyltransferase 2 (MYST2))

Alternative Name: KAT7 (MYST2 Products)

Synonyms: Myst2 antibody, HBO1 antibody, HBOA antibody, MYST2 antibody, ZC2HC7 antibody, Hbo1 antibody, Hboa antibody, lysine acetyltransferase 7 antibody, K(lysine) acetyltransferase 7 antibody, MYST histone acetyltransferase 2 antibody, Kat7 antibody, KAT7 antibody, myst2 antibody

Background:

Description: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (By similarity). Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1 (PubMed:18832067). Specifically represses AR-mediated transcription.

Gene: KAT7

Molecular Weight: 75 kDa

Gene ID: 11143

UniProt: O95251