Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Cyclin T2 antibody (Internal Region)

CCNT2 Reactivity: Human, Mouse, Rat WB, ELISA, ICC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6257122
  • Target See all Cyclin T2 (CCNT2) Antibodies
    Cyclin T2 (CCNT2)
    Binding Specificity
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    Human, Mouse, Rat
    Host
    • 25
    • 2
    Rabbit
    Clonality
    • 25
    • 2
    Polyclonal
    Conjugate
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Cyclin T2 antibody is un-conjugated
    Application
    • 21
    • 13
    • 13
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    CCNT2 Antibody detects endogenous levels of total CCNT2.
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human CCNT2, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product CCNT2 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Expiry Date
    12 months
  • Target
    Cyclin T2 (CCNT2)
    Alternative Name
    CCNT2 (CCNT2 Products)
    Synonyms
    fb16c03 antibody, wu:fb16c03 antibody, wu:fj68b10 antibody, zgc:55690 antibody, ccnt2 antibody, cycT antibody, wu:fi17h07 antibody, zgc:55357 antibody, MGC81210 antibody, CCNT2 antibody, CYCT2 antibody, 2900041I18Rik antibody, C81304 antibody, CycT2 antibody, CycT2b antibody, cyclin T2 antibody, cyclin T2b antibody, cyclin T2a antibody, cyclin T2 S homeolog antibody, CCNT2 antibody, ccnt2b antibody, ccnt2a antibody, ccnt2.S antibody, ccnt2 antibody, Ccnt2 antibody
    Background

    Description: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation, P-TEFB complex interacts with MYOD1, this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes, this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity).

    Gene: CCNT2

    Molecular Weight
    81kDa
    Gene ID
    905
    UniProt
    O60583
You are here:
Support