Casein Kinase 1 delta antibody (Internal Region)

Catalog No. ABIN6257097

Product Details anti-Casein Kinase 1 delta Antibody

Target: Casein Kinase 1 delta (CSNK1D) (Casein Kinase 1, delta (CSNK1D))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Casein Kinase 1 delta antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: Casein Kinase 1 delta Antibody detects endogenous levels of total Casein Kinase 1 delta.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Casein Kinase 1 delta, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for Casein Kinase 1 delta

Target: Casein Kinase 1 delta (CSNK1D) (Casein Kinase 1, delta (CSNK1D))

Alternative Name: CSNK1D (CSNK1D Products)

Synonyms: ASPS antibody, CKIdelta antibody, FASPS2 antibody, HCKID antibody, 1200006A05Rik antibody, AA409348 antibody, D930010H05Rik antibody, CKI-delta antibody, CKId antibody, csnk1d antibody, wu:fb69b03 antibody, wu:fj97a05 antibody, zgc:77627 antibody, CSNK1D antibody, ckIdelta antibody, Csnk1d antibody, csnk1dl antibody, wu:fb50c04 antibody, zgc:63971 antibody, casein kinase 1 delta antibody, casein kinase 1, delta antibody, casein kinase 1, delta b antibody, casein kinase 1 delta S homeolog antibody, casein kinase 1, delta a antibody, CSNK1D antibody, Csnk1d antibody, csnk1d antibody, csnk1db antibody, Bm1_37175 antibody, csnk1d.S antibody, csnk1da antibody

Background:

Description: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.

Gene: CSNK1D

Molecular Weight: 47 kDa

Gene ID: 1453

UniProt: P48730

Pathways: Hedgehog Signaling, M Phase