BMP10 antibody (Internal Region)
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- Target See all BMP10 Antibodies
- BMP10 (Bone Morphogenetic Protein 10 (BMP10))
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Binding Specificity
- Internal Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This BMP10 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
- Specificity
- BMP10 Antibody detects endogenous levels of total BMP10.
- Predicted Reactivity
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human BMP10, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product BMP10 Primary Antibody
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- Application Notes
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- BMP10 (Bone Morphogenetic Protein 10 (BMP10))
- Alternative Name
- BMP10 (BMP10 Products)
- Synonyms
- BMP10 antibody, si:dkey-13n15.5 antibody, Bmp10 antibody, BMP9 antibody, BMP-10 antibody, bone morphogenetic protein 10 antibody, BMP10 antibody, bmp10 antibody, LOC662386 antibody, Bmp10 antibody
- Background
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Description: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
Gene: BMP10
- Molecular Weight
- 48 kDa
- Gene ID
- 27302
- UniProt
- O95393
- Pathways
- Hormone Activity, Regulation of Muscle Cell Differentiation
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