Coxsackie Adenovirus Receptor antibody (N-Term)

Catalog No. ABIN6256932

Product Details anti-Coxsackie Adenovirus Receptor Antibody

Target: Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Coxsackie Adenovirus Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: CXADR Antibody detects endogenous levels of total CXADR.

Predicted Reactivity: Pig,Bovine,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CXADR, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for Coxsackie Adenovirus Receptor

Target: Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))

Alternative Name: CXADR (CXADR Products)

Synonyms: CAR antibody, CAR4/6 antibody, HCAR antibody, Car1 antibody, car antibody, cb331 antibody, fb76g12 antibody, wu:fb76g12 antibody, 2610206D03Rik antibody, AU016810 antibody, AW553441 antibody, MCAR antibody, MCVADR antibody, hcar antibody, xCAR antibody, CXADR antibody, CXADR, Ig-like cell adhesion molecule antibody, coxsackie virus and adenovirus receptor antibody, CXADR, Ig-like cell adhesion molecule L homeolog antibody, CXADR antibody, Cxadr antibody, cxadr antibody, cxadr.L antibody

Background:

Description: Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.

Gene: CXADR

Molecular Weight: 40 kDa

Gene ID: 1525

UniProt: P78310

Pathways: Cell-Cell Junction Organization