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CAMK4 antibody (pThr200)

CAMK4 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6256500
  • Target See all CAMK4 Antibodies
    CAMK4 (Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4))
    Binding Specificity
    • 22
    • 16
    • 12
    • 7
    • 6
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr200
    Reactivity
    • 65
    • 58
    • 41
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 70
    • 11
    Rabbit
    Clonality
    • 64
    • 17
    Polyclonal
    Conjugate
    • 44
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CAMK4 antibody is un-conjugated
    Application
    • 67
    • 29
    • 16
    • 15
    • 14
    • 14
    • 11
    • 6
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    Phospho-CaMK4 (Thr200) Antibody detects endogenous levels of CaMK4 only when phosphorylated at Threonine 200.
    Predicted Reactivity
    Pig,Zebrafish,Horse,Sheep,Dog,Chicken,Xenopus
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human CaMK4 around the phosphorylation site of Thr200.
    Isotype
    IgG
    Top Product
    Discover our top product CAMK4 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    CAMK4 (Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4))
    Alternative Name
    CAMK4 (CAMK4 Products)
    Synonyms
    CaMK IV antibody, CaMK-GR antibody, IV antibody, caMK antibody, CAMK4 antibody, A430110E23Rik antibody, AI666733 antibody, CaMKIV antibody, CaMKIV/Gr antibody, D18Bwg0362e antibody, Ccdpk antibody, RATCCDPK antibody, camk4-A antibody, wu:fj42a03 antibody, zgc:110275 antibody, calcium/calmodulin dependent protein kinase IV antibody, calcium/calmodulin-dependent protein kinase IV antibody, calcium/calmodulin-dependent protein kinase IV L homeolog antibody, CAMK4 antibody, Camk4 antibody, camk4.L antibody, camk4 antibody
    Background

    Description: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

    Gene: CAMK4

    Molecular Weight
    60kDa
    Gene ID
    814
    UniProt
    Q16566
    Pathways
    EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Production of Molecular Mediator of Immune Response, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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