HDAC4 antibody (pSer632)

Catalog No. ABIN6256389

Product Details anti-HDAC4 Antibody

Target: HDAC4 (Histone Deacetylase 4 (HDAC4))

Binding Specificity: pSer632

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: Phospho-HDAC4 (Ser632) Antibody detects endogenous levels of HDAC4 only when phosphorylated at Serine 632.

Predicted Reactivity: Pig,Zebrafish,Bovine,Sheep,Dog,Chicken,Xenopus

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human HDAC4 around the phosphorylation site of Ser632.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for HDAC4

Target: HDAC4 (Histone Deacetylase 4 (HDAC4))

Alternative Name: HDAC4 (HDAC4 Products)

Synonyms: CG1770 antibody, DHDAC4 antibody, Dmel\\CG1770 antibody, GC1770 antibody, HDAC antibody, HDAC4a antibody, dHDAC4 antibody, dmHDA405 antibody, hdac4 antibody, dana_GLEANR_19966 antibody, DanaGF18710 antibody, GF18710 antibody, HDAC4 antibody, AHO3 antibody, BDMR antibody, HA6116 antibody, HD4 antibody, HDAC-4 antibody, HDAC-A antibody, HDACA antibody, 4932408F19Rik antibody, AI047285 antibody, wu:fa96d08 antibody, wu:fc56f08 antibody, zgc:152701 antibody, histone deacetylase 4 antibody, hypothetical protein antibody, Histone deacetylase 4 antibody, GF18710 gene product from transcript GF18710-RC antibody, PTRG_03699 antibody, PGTG_15512 antibody, HDAC4 antibody, Dana\GF18710 antibody, Hdac4 antibody, hdac4 antibody

Background:

Description: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).

Gene: HDAC4

Molecular Weight: 119kDa

Gene ID: 9759

UniProt: P56524

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process