APC antibody (pSer2054)
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- Target See all APC Antibodies
- APC (Adenomatous Polyposis Coli (APC))
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Binding Specificity
- pSer2054
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This APC antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- Phospho-APC (Ser2054) Antibody detects endogenous levels of APC only when phosphorylated at Sersine 2054.
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogen
- A synthesized peptide derived from human APC around the phosphorylation site of Ser2054.
- Isotype
- IgG
- Top Product
- Discover our top product APC Primary Antibody
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anti-Adenomatous Polyposis Coli (APC) (AA 2636-2845) antibody
APC Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (AA 2544-2843) antibodyAPC Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (AA 2634-2842) antibodyAPC Reactivity: Rat WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (AA 2744-2843) antibodyAPC Reactivity: Human WB, ELISA, IF, PLA Host: Mouse Monoclonal 3E2 unconjugated
anti-Adenomatous Polyposis Coli (APC) (C-Term) antibodyAPC Reactivity: Human WB, IHC, ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (AA 2751-2843) antibodyAPC Reactivity: Rat ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) antibodyAPC Reactivity: Human WB, IHC, ELISA Host: Rabbit Monoclonal 5F2 unconjugated Recombinant Antibody
anti-Adenomatous Polyposis Coli (APC) (C-Term) antibodyAPC Reactivity: Human, Mouse, Rat WB, IHC, ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) antibodyAPC Reactivity: Human, Mouse, Rat IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Adenomatous Polyposis Coli (APC) (AA 1-2843) antibodyAPC Reactivity: Human WB, PLA Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- APC (Adenomatous Polyposis Coli (APC))
- Alternative Name
- APC (APC Products)
- Background
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Description: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Gene: APC
- Molecular Weight
- 311kDa
- Gene ID
- 324
- UniProt
- P25054
- Pathways
- WNT Signaling, Stem Cell Maintenance, Cell-Cell Junction Organization
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