TMEM106B antibody (AA 218-252)

Catalog No. ABIN6244143

Product Details anti-TMEM106B Antibody

Target: TMEM106B (Transmembrane Protein 106B (TMEM106B))

Binding Specificity: AA 218-252

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM106B antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Predicted Reactivity: B, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TMEM106B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 218-252 amino acids from human TMEM106B.

Clone: RB56763

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-TMEM106B antibody (ABIN6244143)

Jiang, Cao, Sawaya, Abskharon, Ge, DeTure, Dickson, Fu, Ogorzalek Loo, Loo, Eisenberg: "Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43." in: Nature, Vol. 605, Issue 7909, pp. 304-309, (2022) (PubMed).

Target Details for TMEM106B

Target: TMEM106B (Transmembrane Protein 106B (TMEM106B))

Alternative Name: TMEM106B (TMEM106B Products)

Background: Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.

Molecular Weight: 31127

UniProt: Q9NUM4