RBMX antibody (AA 222-252)

Catalog No. ABIN6244062

Product Details anti-RBMX Antibody

Target: RBMX (RNA Binding Motif Protein, X-Linked (RBMX))

Binding Specificity: AA 222-252

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBMX antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RBMX antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 222-252 amino acids from the Central region of human RBMX.

Clone: RB53800

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for RBMX

Target: RBMX (RNA Binding Motif Protein, X-Linked (RBMX))

Alternative Name: RBMX (RBMX Products)

Synonyms: hnRNP G antibody, HNRNPG antibody, HNRPG antibody, RBMXP1 antibody, RBMXRT antibody, RNMX antibody, hnRNP-G antibody, fc66e11 antibody, wu:fb37c07 antibody, wu:fc66e11 antibody, hnrnpg antibody, hnrpg antibody, rbmxp1 antibody, rbmxrt antibody, rnmx antibody, RBMXL1 antibody, RNA binding motif protein, X chromosome antibody, RNA binding motif protein, X-linked antibody, RNA binding motif protein, X-linked S homeolog antibody, Rbmx antibody, RBMX antibody, rbmx antibody, rbmx.S antibody

Background: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter, may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion, acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single- stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation, probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways, promotes both the IL-1- beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.

Molecular Weight: 42332

UniProt: P38159

Pathways: Chromatin Binding, Ribonucleoprotein Complex Subunit Organization