USP2 antibody (AA 1-258)

Catalog No. ABIN6244029

Product Details anti-USP2 Antibody

Target: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Binding Specificity: AA 1-258

Reactivity: Human, Green Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This USP2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This USP2 antibody is generated from a mouse immunized with a recombinant protein between 1-258 amino acids from human USP2.

Clone: 1738CT331-50-87

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for USP2

Target: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Alternative Name: USP2 (USP2 Products)

Synonyms: UBP41 antibody, USP9 antibody, B930035K21Rik antibody, Ubp41 antibody, UBP-t antibody, UBP46 antibody, ubp52 antibody, ubp66 antibody, zgc:92134 antibody, ubiquitin specific peptidase 2 antibody, ubiquitin specific peptidase 2a antibody, USP2 antibody, Usp2 antibody, usp2a antibody

Background: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity).

Molecular Weight: 68072

UniProt: O75604