SPPL2B antibody (AA 196-229)

Catalog No. ABIN6243975

Product Details anti-SPPL2B Antibody

Target: SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Binding Specificity: AA 196-229

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPPL2B antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SPPL2B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 196-229 amino acids from the Central region of human SPPL2B.

Clone: RB53139

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for SPPL2B

Target: SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Alternative Name: SPPL2B (SPPL2B Products)

Synonyms: SPPL2B antibody, wu:fc16e01 antibody, wu:fc85d12 antibody, zgc:136525 antibody, MGC147524 antibody, IMP-4 antibody, IMP4 antibody, PSH4 antibody, PSL1 antibody, 3110056O03Rik antibody, AW550292 antibody, RGD1308556 antibody, signal peptide peptidase-like 2 antibody, signal peptide peptidase like 2B antibody, signal peptide peptidase like 2B S homeolog antibody, signal peptide peptidase-like 2B antibody, sppl2 antibody, sppl2b antibody, sppl2b.S antibody, SPPL2B antibody, Sppl2b antibody

Background: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF- alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity.

Molecular Weight: 64644

UniProt: Q8TCT7