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ITK antibody (AA 228-262)

ITK Reactivity: Human WB Host: Rabbit Polyclonal RB50773 unconjugated
Catalog No. ABIN6243870
  • Target See all ITK Antibodies
    ITK (IL2-Inducible T-Cell Kinase (ITK))
    Binding Specificity
    • 14
    • 10
    • 9
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 228-262
    Reactivity
    • 48
    • 19
    • 12
    • 6
    • 3
    Human
    Host
    • 61
    • 4
    • 2
    Rabbit
    Clonality
    • 63
    • 4
    Polyclonal
    Conjugate
    • 28
    • 7
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ITK antibody is un-conjugated
    Application
    • 40
    • 36
    • 14
    • 14
    • 11
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    M
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This ITK antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 228-262 amino acids from the Central region of human ITK.
    Clone
    RB50773
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ITK Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Target
    ITK (IL2-Inducible T-Cell Kinase (ITK))
    Alternative Name
    ITK (ITK Products)
    Synonyms
    Emt antibody, Tcsk antibody, Tsk antibody, EMT antibody, LPFS1 antibody, LYK antibody, PSCTK2 antibody, IL2 inducible T cell kinase antibody, IL2 inducible T-cell kinase antibody, IL2-inducible T-cell kinase antibody, Itk antibody, ITK antibody
    Background
    Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.
    Molecular Weight
    71831
    UniProt
    Q08881
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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