This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This SEMA7A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 521-555 amino acids from the C-terminal region of human SEMA7A.
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.