FBXW7 antibody (N-Term)
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- Target See all FBXW7 Antibodies
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
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Binding Specificity
- AA 177-208, N-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FBXW7 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This FBXW7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 177-208 amino acids from the N-terminal region of human FBXW7.
- Clone
- RB51853
- Isotype
- Ig Fraction
- Top Product
- Discover our top product FBXW7 Primary Antibody
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- Application Notes
- WB: 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Expiry Date
- 6 months
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- Target
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
- Alternative Name
- FBXW7 (FBXW7 Products)
- Synonyms
- cdc4 antibody, AGO antibody, CDC4 antibody, FBW6 antibody, FBW7 antibody, FBX30 antibody, FBXO30 antibody, FBXW6 antibody, SEL-10 antibody, SEL10 antibody, hAgo antibody, hCdc4 antibody, 1110001A17Rik antibody, Cdc4 antibody, Fbw7 antibody, Fbwd6 antibody, Fbx30 antibody, Fbxo30 antibody, Fbxw6 antibody, F-box and WD repeat domain containing 7 antibody, F-box and WD-40 domain protein 7 antibody, Fbxw7 antibody, FBXW7 antibody, fbxw7 antibody
- Background
- Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
- Molecular Weight
- 79663
- UniProt
- Q969H0
- Pathways
- Notch Signaling, EGFR Signaling Pathway
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