FZD10 antibody (N-Term)

Catalog No. ABIN6243622

Product Details anti-FZD10 Antibody

Target: FZD10 (Frizzled Family Receptor 10 (FZD10))

Binding Specificity: AA 177-212, N-Term

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FZD10 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FZD10 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 177-212 amino acids from the N-terminal region of human FZD10.

Clone: RB52084

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for FZD10

Target: FZD10 (Frizzled Family Receptor 10 (FZD10))

Alternative Name: FZD10 (FZD10 Products)

Background: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Molecular Weight: 65336

UniProt: Q9ULW2

Pathways: WNT Signaling