CSK antibody (N-Term)

Catalog No. ABIN6243612

Product Details anti-CSK Antibody

Target: CSK (C-Src tyrosine Kinase (CSK))

Binding Specificity: AA 67-101, N-Term

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSK antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: B, H, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Csk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 67-101amino acids from the N-terminal region of human Mouse Csk.

Clone: RB50568

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for CSK

Target: CSK (C-Src tyrosine Kinase (CSK))

Alternative Name: Csk (CSK Products)

Synonyms: AW212630 antibody, C-terminal Src kinase antibody, c-src tyrosine kinase antibody, CSK, non-receptor tyrosine kinase antibody, CSK antibody, Csk antibody

Background: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).

Molecular Weight: 50716

UniProt: P41241

Pathways: TCR Signaling, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events