ITGA7 antibody (C-Term)

Catalog No. ABIN6243591

Product Details anti-ITGA7 Antibody

Target: ITGA7 (Integrin, alpha 7 (ITGA7))

Binding Specificity: AA 1149-1181, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGA7 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ITGA7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1149-1181 amino acids from the C-terminal region of human ITGA7.

Clone: RB52832

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:8000. WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ITGA7 antibody (ABIN6243591)

Ming, Fu, Zhang, Qin, Cao, Chan, Ma, Xie, Guan: "Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma." in: Nature communications, Vol. 7, pp. 13568, (2018) (PubMed).

Target Details for ITGA7

Target: ITGA7 (Integrin, alpha 7 (ITGA7))

Alternative Name: ITGA7 (ITGA7 Products)

Synonyms: [a]7 antibody, alpha7 antibody, integrin alpha 7 antibody, integrin subunit alpha 7 antibody, Itga7 antibody, ITGA7 antibody

Background: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.

Molecular Weight: 128948

UniProt: Q13683

Pathways: Integrin Complex