This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This Mouse Bmi1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 109-143 amino acids from the Central region of Mouse Bmi1.
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).