GPR56 antibody

Catalog No. ABIN6243208

Product Details anti-GPR56 Antibody

Target: GPR56 (G Protein-Coupled Receptor 56 (GPR56))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GPR56 antibody is un-conjugated

Application: Western Blotting (WB)

Immunogen: This antibody is generated from a mouse immunized with a recombinant protein.

Clone: 1443CT377-65-29

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for GPR56

Target: GPR56 (G Protein-Coupled Receptor 56 (GPR56))

Alternative Name: GPR56 (GPR56 Products)

Background: Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA, unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis.

Molecular Weight: 77738

UniProt: Q9Y653