GAB1 antibody

Catalog No. ABIN6243205

Product Details anti-GAB1 Antibody

Target: GAB1 (GRB2-Associated Binding Protein 1 (GAB1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GAB1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This Gab1 antibody is generated from mice immunized with a GST fusion protein encoding full length human GAB1.

Clone: 1AT1979

Isotype: IgG1

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-GAB1 antibody (ABIN6243205)

Fan, Wong, Marino, Ou, Shen, Wu, Wong, Reiser, Johnson: "Acquired substrate preference for GAB1 protein bestows transforming activity to ERBB2 kinase lung cancer mutants." in: The Journal of biological chemistry, Vol. 288, Issue 23, pp. 16895-904, (2013) (PubMed).

Sun, Yuan, Liu, Shi, Baker, Vuori, Wu, Feng: "Role of Gab1 in UV-induced c-Jun NH2-terminal kinase activation and cell apoptosis." in: Molecular and cellular biology, Vol. 24, Issue 4, pp. 1531-9, (2004) (PubMed).

Target Details for GAB1

Target: GAB1 (GRB2-Associated Binding Protein 1 (GAB1))

Alternative Name: Gab1 (GAB1 Products)

Synonyms: AA408973 antibody, AW107238 antibody, growth factor receptor bound protein 2-associated protein 1 antibody, GRB2-associated binding protein 1 antibody, GRB2 associated binding protein 1 antibody, Gab1 antibody, GAB1 antibody

Background: The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 76616

NCBI Accession: NP_002030, NP_997006

UniProt: Q13480

Pathways: RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals