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SREBF chaperone antibody (N-Term)

SCAP Reactivity: Human WB Host: Mouse Monoclonal 1992C245-37-16 unconjugated
Catalog No. ABIN6243003
  • Target See all SREBF chaperone (SCAP) Antibodies
    SREBF chaperone (SCAP)
    Binding Specificity
    • 15
    • 7
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 49-83, N-Term
    Reactivity
    • 27
    • 18
    • 17
    • 1
    Human
    Host
    • 41
    • 1
    Mouse
    Clonality
    • 41
    • 1
    Monoclonal
    Conjugate
    • 16
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SREBF chaperone antibody is un-conjugated
    Application
    • 33
    • 13
    • 13
    • 12
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogen
    This SCAP antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 49-83 amino acids from the N-terminal region of human SCAP.
    Clone
    1992C245-37-16
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product SCAP Primary Antibody
  • Application Notes
    WB: 1:4000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Target
    SREBF chaperone (SCAP)
    Alternative Name
    SCAP (SCAP Products)
    Synonyms
    9530044G19 antibody, mKIAA0199 antibody, SREBF chaperone antibody, SREBF chaperone S homeolog antibody, SCAP antibody, Scap antibody, scap.S antibody
    Background
    Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).
    Molecular Weight
    139729
    UniProt
    Q12770
    Pathways
    SARS-CoV-2 Protein Interactome
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