STUB1 antibody

Catalog No. ABIN6242870

Product Details anti-STUB1 Antibody

Target: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This STUB1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This STUB1 antibody is generated from a mouse immunized with a recombinant protein of human STUB1.

Clone: 1008CT12-4-1

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 1:4000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for STUB1

Target: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Alternative Name: STUB1 (STUB1 Products)

Synonyms: CHIP antibody, HSPABP2 antibody, NY-CO-7 antibody, SDCCAG7 antibody, UBOX1 antibody, 0610033N24Rik antibody, 2210017D18Rik antibody, 2310040B03Rik antibody, AW046544 antibody, Chip antibody, wu:fc22f04 antibody, zgc:56076 antibody, STUB1 antibody, chip antibody, ATCHIP antibody, CARBOXYL TERMINUS OF HSC70-INTERACTING PROTEIN antibody, carboxyl terminus of HSC70-interacting protein antibody, STIP1 homology and U-box containing protein 1 antibody, STIP1 homology and U-Box containing protein 1 antibody, STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase L homeolog antibody, STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase antibody, STIP1 homology and U box-containing protein 1 antibody, carboxyl terminus of HSC70-interacting protein antibody, STUB1 antibody, Stub1 antibody, stub1 antibody, stub1.L antibody, LOC100282870 antibody, CHIP antibody

Background: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation.

Molecular Weight: 34856

UniProt: Q9UNE7

Pathways: Regulation of Hormone Metabolic Process, Response to Water Deprivation