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Sonic Hedgehog antibody (C-Term)

SHH Reactivity: Mouse WB, FACS Host: Rabbit Polyclonal RB51214 unconjugated
Catalog No. ABIN6242829
  • Target See all Sonic Hedgehog (SHH) Antibodies
    Sonic Hedgehog (SHH)
    Binding Specificity
    • 15
    • 12
    • 9
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 397-431, C-Term
    Reactivity
    • 67
    • 49
    • 37
    • 17
    • 10
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse
    Host
    • 73
    • 12
    • 8
    • 1
    • 1
    Rabbit
    Clonality
    • 67
    • 28
    Polyclonal
    Conjugate
    • 52
    • 8
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Sonic Hedgehog antibody is un-conjugated
    Application
    • 69
    • 28
    • 23
    • 14
    • 13
    • 11
    • 10
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This Mouse Shh antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 397-431 amino acids from the C-terminal region of mouse Shh.
    Clone
    RB51214
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SHH Primary Antibody
  • Application Notes
    WB: 1:1000. FC: 1:25
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Target
    Sonic Hedgehog (SHH)
    Alternative Name
    Shh (SHH Products)
    Background
    Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity).
    Molecular Weight
    47773
    UniProt
    Q62226
    Pathways
    Hedgehog Signaling, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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