UNC5B antibody (AA 507-541)

Catalog No. ABIN6242756

Product Details anti-UNC5B Antibody

Target: UNC5B (Netrin receptor UNC5B (UNC5B))

Binding Specificity: AA 507-541

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNC5B antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This UNC5B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 507-541 amino acids from the Central region of human UNC5B.

Clone: RB52980

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for UNC5B

Target: UNC5B (Netrin receptor UNC5B (UNC5B))

Alternative Name: UNC5B (UNC5B Products)

Background: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.

Molecular Weight: 103638

UniProt: Q8IZJ1