SYNE2 antibody (AA 1843-1877)

Catalog No. ABIN6242751

Product Details anti-SYNE2 Antibody

Target: SYNE2 (Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2))

Binding Specificity: AA 1843-1877

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYNE2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SYNE2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1843-1877 amino acids from human SYNE2.

Clone: RB56750

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for SYNE2

Target: SYNE2 (Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2))

Alternative Name: SYNE2 (SYNE2 Products)

Synonyms: EDMD5 antibody, NUA antibody, NUANCE antibody, Nesp2 antibody, Nesprin-2 antibody, SYNE-2 antibody, TROPH antibody, SYNE2 antibody, nua antibody, edmd5 antibody, nuance antibody, syne-2 antibody, nesprin-2 antibody, 6820443O06Rik antibody, AW546258 antibody, D12Ertd777e antibody, Nesp2g antibody, mKIAA1011 antibody, RGD1305248 antibody, spectrin repeat containing nuclear envelope protein 2 antibody, spectrin repeat containing, nuclear envelope 2 antibody, SYNE2 antibody, syne2 antibody, Syne2 antibody

Background: Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein- containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for centrosome migration to the apical cell surface during early ciliogenesis.

Molecular Weight: 796442

UniProt: Q8WXH0

Pathways: Maintenance of Protein Location