This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This TFCP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 282-316 amino acids from the Central region of human TFCP2.
Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.