Nicastrin antibody (AA 99-133)

Catalog No. ABIN6242494

Product Details anti-Nicastrin Antibody

Target: Nicastrin (NCSTN)

Binding Specificity: AA 99-133

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nicastrin antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NCSTN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 99-133 amino acids from human NCSTN.

Clone: RB53031

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:8000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for Nicastrin

Target: Nicastrin (NCSTN)

Alternative Name: NCSTN (NCSTN Products)

Background: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.

Molecular Weight: 78411

UniProt: Q92542

Pathways: Notch Signaling, Neurotrophin Signaling Pathway