CHD5 antibody (AA 64-98)

Catalog No. ABIN6242241

Product Details anti-CHD5 Antibody

Target: CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))

Binding Specificity: AA 64-98

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHD5 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CHD5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 64-98 amino acids from human CHD5.

Clone: RB54755

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for CHD5

Target: CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))

Alternative Name: CHD5 (CHD5 Products)

Synonyms: CHD-5 antibody, 4930532L22Rik antibody, AW060752 antibody, B230399N07Rik antibody, CHD5 antibody, chromodomain helicase DNA binding protein 5 antibody, potassium voltage-gated channel subfamily A regulatory beta subunit 2 antibody, CHD5 antibody, Chd5 antibody, chd5 antibody, KCNAB2 antibody

Background: Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non- methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys- 27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.

Molecular Weight: 223050

UniProt: Q8TDI0