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HGS antibody

HGS Reactivity: Human, Mouse, Rat WB, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6241891
  • Target See all HGS Antibodies
    HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))
    Reactivity
    • 44
    • 30
    • 21
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 38
    • 5
    • 1
    Rabbit
    Clonality
    • 41
    • 3
    Polyclonal
    Conjugate
    • 32
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HGS antibody is un-conjugated
    Application
    • 36
    • 21
    • 19
    • 15
    • 10
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Immunogen
    Synthetic Peptide
    Top Product
    Discover our top product HGS Primary Antibody
  • Application Notes
    IF: 1:100. WB: 1:1000. IHC: 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Storage
    4 °C,-20 °C
  • Target
    HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))
    Alternative Name
    HGS (HGS Products)
    Synonyms
    HRS antibody, Hrs antibody, fi34f05 antibody, zgc:63492 antibody, wu:fi34f05 antibody, Hgr antibody, ZFYVE8 antibody, CG2903 antibody, Dmel\\CG2903 antibody, HRS-2 antibody, Vps27 antibody, hrs antibody, l(2)23AB5 antibody, l(2)23Ad antibody, l(2)23Ad(Hrs) antibody, vps27 antibody, hgs antibody, hepatocyte growth factor-regulated tyrosine kinase substrate antibody, HGF-regulated tyrosine kinase substrate antibody, Hepatocyte growth factor regulated tyrosine kinase substrate antibody, hepatocyte growth factor-regulated tyrosine kinase substrate L homeolog antibody, HGS antibody, Hgs antibody, hgs antibody, Hrs antibody, hgs.L antibody
    Background
    Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
    UniProt
    O14964
    Pathways
    EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Synaptic Vesicle Exocytosis, EGFR Downregulation
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